E Evaluation and Test of Activity of Anti-Acne Peel-Off Mask Preparation Formulation of Brotowali Stem Extract (Tinospora crispa L.)
Evaluation and Test of Activity of Anti-Acne Peel-Off Mask Preparation Formulation of Brotowali Stem Extract (Tinospora crispa L.)
DOI:
https://doi.org/10.33859/jpcs.v4i1.419Keywords:
Propionibacterium acnes, Peel-off Mask, Evaluation, Brotowali stemAbstract
Background: Facial skin care for acne treatment is better formulated in topical form, this is due to the duration of the active substances that interact with the skin. One dosage form is a peel-off mask with active substances brotowali stems which contain flavanoids, tannins, alkaloids as antibacterial causes acne.
Objective: Analyzing the effect of variations in the concentration of brotowali stem extract (Tinospora crispa L.) on physicochemical evaluation and antibacterial activity of optimal anti-acne peel-off mask preparation formulations
Methods: The research method used is True Experimental with a posttest only control group design research design. Make peel-off mask formulations with variations in extract concentrations of 20%, 30%, and 40%. The evaluation then includes organoleptis, homogeneity, dispersion, adhesion, dry time, pH, viscosity, and antibacterial activity tests, statistically analyzed using One Way ANOVA
Results: Qualify in the organoleptis test is formula II (30%) and III (40%), the dispersion test is formula I (20%) and II (30%) with a p-value of 0.022, the adhesion test of all formulations with a p-value of 0.014, the dry time test of all formulations with a p-value of 0.000, the pH test is formula I (20%) with a p-value of 0.000, the viscosity test is formula II (30%) with a p-value of 0.000. The diameter of the formula's third inhibitory zone against propionibacterium acnes was 8.61mm ± 0.19 respectively; 14.31mm ± 3.88, and 15.54mm ± 4.80 with a p-value of 0.012
Conclusion: Variations on concentration of brotowali stem extract have an influence on physicochemical evaluation and antibacterial activity, the most optimal formulation is formulation II (30%)
References
Agustini, N. W. S., Apriastini, M., & Susilowati, Y. (2021). Formulasi Ekstrak Etanol Mikroalga Chroococcus turgidus untuk Sediaan Masker Peel-off sebagai Antibakteri. Warta Industri Hasil Pertanian, 38(2), 142–152.
Ariani, L. W., & Wigati, D. (2016). Formulasi Masker Gel Peel-Off Ekstrak Etanol Kulit Buah Jeruk Manis (Citrus sinensis (L.) Osbeck) Sebagai Obat Jerawat. Media Farmasi Indonesia, 11(2).
Budiman, A., Aulifa, D. L., Kusuma, A. S. W., Kurniawan, I. S., & Sulastri, A. (2017). Peel-off gel formulation from black mulberries (Morus nigra) extract as anti-acne mask. National Journal of Physiology, Pharmacy and Pharmacology, 7(9), 987–994. https://doi.org/10.5455/njppp.2017.7.0413123052017
Fauziah, Marwarni, R., & Adriani, A. (2020). Formulasi Dan Uji Sifat Fisik Masker Wajah Peel-Off Dari Ekstrak Sabut Kelapa ( Cocos nucifera L). Jurnal Riset Kefarmasian Indonesia, 2(1).
Firmansyah, F., Kholifah, H., & Chabib, L. (2022). Formulasi Gel Hand Sanitizer Ekstrak Buah Belimbing Wuluh dengan Variasi Karbopol 940 dan HPMC. J. Islamic Pharm. Online, 7(1), 69–73. https://doi.org/10.18860/jip.v7i1.13839
Fitriani, I., Lubis, M. S., Yuniarti, R., & Rahayu, P. Y. (2022). Perbandingan Efektivitas Produk Topikal Anti Jerawat Terhadap Tikus Putih Jantan (Rattus novergicus) Secara In Vivo. Jurnal Farmasi, Sains, Dan Kesehatan, 2(1).
Harliantika, Y., & Noval. (2021). Formulasi dan Evaluasi Hidrogel Ekstrak Etanol Daun Gaharu (Aquilaria malacensis Lamk.) dengan Kombinasi Basis Karbopol 940 dan HPMC K4M. Journal of Pharmaceutical Care Anwar Medika, 55(2), 2021.
Khairany, N., Idiawati, N., & Wibowo, A. M. (2015). Analisis Sifat Fisik dan Kimia Gel Ekstrak Etanol Daun Talas (Colocasia esculenta (L.) Schott). 4(2), 81–88.
Khasanah, R. M., & Susilowati, D. (2020). Formulasi Masker Gel Peel-Off Ekstrak Etanol Daun Petai Cina (Leucaena Leuccocephala) Sebagai Antijerawat Antibakteri. IJMS-Indonesian Journal On Medical Science, 7(1).
Lutfiana, S. I., Dellima, B. R. E. M., & Rosita, M. E. (2021). Formulasi Dan Uji Sifat Fisik Masker Gel Peel-Off Serbuk Biji Salak (Salacca zalacca (Gaertn.) Voss). Jurnal Farmasi Dan Kesehatan Indonesia, 1(2).
Mutmainnah, Abdullah, A., & Syawie, M. (2022). Formulasi Dan Evaluasi Fisik Masker Gel Peel Off Dari Serbuk Sisik Ikan Mujair (Oreochromis mossambicus). Jurnal Riset Kefarmasian Indonesia, 4(3), 321–331.
Nurwaini, S., & Saputri, I. D. (2018). Pengujian Sifat Fisik dan Aktivitas Antibakteri Sediaan Gel Hand Sanitizer Ekstrak Daun Lidah Mertua (Sansevieria trifasciata Prain). Talenta Conference Series: Tropical Medicine (TM), 1(3), 078–085. https://doi.org/10.32734/tm.v1i3.266
Pariury, J. A., Paul Christian Herman, J., Rebecca1, T., Veronica, E., Kamasan, G., & Arijana, N. (2021). Potensi Kulit Jeruk Bali (Citrus Maxima Merr) Sebagai Antibakteri Propionibacterium acne Penyebab Jerawat. In HTMJ (Vol. 19, Issue 1). www.journal-medical.hangtuah.ac.id
Permadi, A., Suhendra, Ahda, M., Padya, S. A., Bachtiar, A. R., Rahma, A. N., Syafitri, E. N., Harmony, V. I. S., & Triwidyastuti, Y. (2022). Pemanfaatan Spirulina Platensis Sebagai Masker Gel Peel-Off. Jurnal Pendidikan Dan Konseling, 4(5), 2260–2268.
Puluh, E. A., Edy, H. J., & Siampa, J. P. (2019). Uji Antibakteri Sediaan Masker Peel Off Ekstrak Etanol Daun Alpukat (Persea ameicana Mill.) terhadap Bakteri Staphylococcus epidermidis sebagai Antijerawat. JURNAL MIPA, 8(3), 101–104.
Putri, R., Supriyanta, J., & Adhil, D. A. (2021). Formulasi dan Uji Aktivitas Sediaan Masker Gel Peel Off Ekstrak Etanol 70% Daun Rambutan (Nephelium Lappaceum L.) Terhadap Propionibacterium Acnes. Journal of Pharmaceutical and Health Research, 2(1), 12–20. https://doi.org/10.47065/jharma.v2i1.836
Ramadanti, A., Rahmasari, D., Maulana, W., Rahayu, D. E., Asshidiq, M. I., & Nugraheni, R. W. (2021). Formulasi Masker Peel-Off Ekstrak Daun Kemangi (Ocimum sanctum) Sebagai Sediaan Anti Jerawat. Medical Sains, 6(1), 57–64.
Ramadeni, R. W. (2022). Formulasi dan Evaluasi Sediaan Facial Wash Gel Ekstrak Daun Kersen (Muntingia calabura L) Sebagai Antioksidan.
Reveny, J., Nazliniwaty, & Umayah, R. (2016). Formulation Of Peel-Off Mask From Ethanol Extract Of Water Spinach Leaves As Anti Aging. International Journal of PharmTech Research, 9(12), 554–559.
Satrimafitrah, P., Afdal, M., Jusman, Razak, Abd. R., Ridhay, A., & Inda, N. I. (2022). Viskositas dan Aktivitas Antibakteri Sabun Cair Berbasis VCO dengan Penambahan Ekstrak Etanol Daun Kelor (Moringa oleifera) Terhadap Bakteri Patogen. Jurnal Riset Kimia, 8(1), 74–82. https://doi.org/10.22487/kovalen.2022.v8.i1.15846
Sholikhah, M., & Apriyanti, R. (2019). Formulasi Dan Karakterisasi Fisik Masker Gel Peel-Off Ekstrak Lengkuas (Alpinia galanga, (L.) Sw). Jurnal Ilmu Farmasi Dan Farmasi Klinik (JIFFK), 16(2), 99–104. www.unwahas.ac.id/publikasiilmiah/index.php/ilmufarmasidanfarmasiklinik
Slamet, S., Anggun, B. D., & Pambudi, D. B. (2020). Uji Stabilitas Fisik Formula Sediaan Gel Ekstrak Daun Kelor (Moringa Oleifera Lamk.). Jurnal Ilmiah Kesehatan, 8(2), 115–122.
Susanti, L., Widodo, S., Bahri, S., & Indriasari, D. W. (2016). Uji Formulasi Sediaan Salep Ekstrak Batang Brotowali (Tinospora crispa L. Miers ) Kombinasi Zeolit Terhadap Bakteri Staphylococcus aureus dan Pseudomonas aeruginosa. Jurnal Kelitbangan.
Utami, W., Mardawati, E., & Putri, S. H. (2020). Pengujian Aktivitas Antioksidan Kulit Buah Naga Merah (Hylocereus polyrhizus) Sebagai Masker Gel Peel Off. Jurnal Industri, 2(1), 95–102. http://jurnal.unpad.ac.id/justin
Wahyuni, D. F., Mustary, M., Syafruddin, S., & Deviyanti, D. (2022). Formulasi Masker Gel Peel Off dari Kulit Pisang Ambon (Musa Paradisiaca Var). Jurnal Sains Dan Kesehatan, 4(1), 48–55. https://doi.org/10.25026/jsk.v4i1.875
Yusriani, Ermawati, & Dewi, R. (2018). Uji Daya Hambat Krim Ekstrak Batang Brotowali (Tinospora crispa L.) Terhadap Propionibacterium acnes. Jurnal Kesehatan, 2.
Zarwinda, I., Elfariyanti, Adriani, A., & Agustina, M. (2022). Formulasi Sediaan Gel Hand Sanitizer Dari Ekstrak Etanol Daun Belimbing Wuluh (Averhoa Blimbi L.) Kombinasi Gel Lidah Buaya (Aloe Vera). Jurnal Kedokteran Dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya, 9(3), 321–330. https://doi.org/10.32539/jkk.v9i3.18939
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Journal Pharmaceutical Care and Sciences
This work is licensed under a Creative Commons Attribution 4.0 International License.