F Formulasi Dan Evaluasi Sediaan Essence Ekstrak  Daun Sirih Hijau (Piper Betle L.) Sebagai Anti Jerawat: Formulasi Dan Evaluasi Sediaan Essence Ekstrak  Daun Sirih Hijau (Piper Betle L.) Sebagai Anti Jerawat

Sinta Dewi; Siti Malahayati; Putri Vidiasari Darsono

doi:10.33859/jpcs.v4i1.425

Authors

Sinta Dewi a:1:{s:5:"en_US";s:22:"Universitas Sari Mulia";}
Siti Malahayati Sari Mulia University
Putri Vidiasari Darsono Sari Mulia University

DOI:

https://doi.org/10.33859/jpcs.v4i1.425

Keywords:

Piper betle, Acne, Propionibacterium acnes

Abstract

Background: Piper betel leaf extract has antibacterial activity against P.acnes because it contains tannins, flavonoids, alkaloids, and terpenoid compounds.

Objective: The purpose of this study is to formulate piper betel leaf extract in the form of essence that meets the requirements of physical quality and has antibacterial activity against P.acnes.

Methods: This study uses true experimental method and well diffusion method for antibacterial test. The essence preparation was made with 3 different extract concentrations (concentrations of 5%, 10%, and 20%), then a physical evaluation was carried out and then the formulation was tested for antibacterial activity against P.acnes. The data obtained were statistically analyzed ANOVA with a significance value of 0.05.

Results: The results showed that the essence preparation had a yellowish-brown to dark brown color, liquid form and characteristic smell of betel leaves with a pH of 5.4-5.5, homogeneous preparation, viscosity 324-463, dispersion power 9.74 mm-11.62mm, and in antibacterial activity tests showed the ability to inhibit the growth of P.acnes bacteria by having inhibitory power that was categorized as strong.

Conclusion: The results of the physical evaluation and the results of the antibacterial activity test for essence preparations had a significant effect on variations in extract concentrations because the p-value was <0.05. Based on the evaluation results, all formulas met the specifications, and the most optimal was formula II

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