E Effectiveness Of Rosuvastatin And Pravastatin as Anti-Dyslipidemia in Male Rats
DOI:
https://doi.org/10.33859/jpcs.v4i2.485Keywords:
Cholesterol total, Rosuvastatin, Pravastatin, Anti-dyslipidemiaAbstract
Background: Dyslipidemia is a disease that can have a negative impact on human health. Dyslipidemia treatment has 3 levels based on intensity, namely disease with high intensity, medium intensity, and low intensity. In this study, the drugs used were Pravastatin and Rosuvastatin, both of which were of medium intensity.
Objective: Knowing the comparison of the effectiveness of the drugs Rosuvastatin and Pravastatin as anti-dyslipidemia in rats.
Methods: The research method used in this study is True Experimental. The research design used in this study was the posttest only control group, namely by taking samples after being given the drugs Rosuvastatin and Pravastatin, so that it would be seen the effectiveness of the treatment given to the group of rats tested.
Results: Rosuvastatin can lower LDL cholesterol better than Pravastatin
because rosuvastatin has the highest binding interaction with HMG-CoA reductase, resulting in the strongest inhibition of cholesterol synthesis of all other statin groups. Pravastatin has the ability to lower LDL. From the results of the average values of the two statin class drugs, Rosuvastatin has a better average value than Pravastatin, but the statistical results can be concluded that there is no significant difference from the 0.5% Na CMC control to Rosuvastatin compared to Pravastatin.
Conclusion: The statin class drug Rosuvastatin has better effectiveness than Pravastatin.
References
Adelina. (2018). Mekanisme Katekin Sebagai Obat Antidislipidemia (Uji In Silico). Buletin Penelitian Kesehatan, 46(3), 147–154. https://doi.org/10.22435/bpk.v46i3.899
Aswania. (2020). Dislipidemia sebagai prediktor kejadian kardiovaskular mayor pada pasien infark miokard akut. Jurnal Medika Udayana, 9(11), 91–100. https://ocs.unud.ac.id/index.php/eum/article/view/71028
Bajaj. (2020). Rosuvastatin Associated Adverse Effects and Drug Interactions In The Clinical Setting of Dyslipidemia. Treasure Island (FL): StatPearls Publishing.
Barter, P. J., Palmer, M. K., & Nicholls, S. J. (2010). Effect of statins on HDL-C: A complex process unrelated to changes in LDL-C: Analysis of the VOYAGER database. Journal of Lipid Research, 51(6), 1546–1553. https://doi.org/10.1194/jlr.P002816
Brown, W. V., Bays, H. E., Hassman, D. R., McKenney, J., Chitra, R., Hutchinson, H., & Miller, E. (2002). Efficacy and safety of rosuvastatin compared with pravastatin and simvastatin in patients with hypercholesterolemia: A randomized, double-blind, 52-week trial. American Heart Journal, 144(6), 1036–1043. https://doi.org/10.1067/mhj.2002.129312
Christalisana, C. (2018). Pengaruh Pengalaman Dan Karakter Sumber Daya Manusia Konsultan Manajemen Konstruksi Terhadap Kualitas Pekerjaan Pada Proyek Di Kabupaten Pandeglang. Jurnal Fondasi, 7(1), 87–98. https://doi.org/10.36055/jft.v7i1.3305
Dipiro. (2015). Pharmacoterapy A Phatophysiologic Approach. In United State: McGraw-Hill Education.
Grundy. (2019). Understanding Cholesterol Levels. Postgraduate Medicine, 108(7), 125–126. https://doi.org/10.3810/pgm.2005.08.1724
Gunawan, H., Sitorus, P., & Rosidah, R. (2018). Pengaruh Pemberian Ekstrak Etanol Herba Poguntano (Picria FelTerrae Lour.) Terhadap Profil Lipid Tikus Putih Jantan Dislipidemia. Talenta Conference Series: Tropical Medicine (TM), 1(1), 230–236. https://doi.org/10.32734/tm.v1i1.81
Hague. (2016). Long-term effectiveness and safety of pravastatin in patients with coronary heart disease. Circulation, 133(19), 1851–1860.
Hairunnisa, H. (2019). Sulitnya Menemukan Obat Baru di Indonesia. Farmasetika.com (Online), 4(1), 16. https://doi.org/10.24198/farmasetika.v4i1.22517
Hasim. (2018). Aktivitas Antioksidan Dan Antihiperkolesterolemia in Vitro Dari Campuran Ekstrak Angkak Dan Bekatul. Jurnal Teknologi dan Industri Pangan, 29(2), 145–154. https://doi.org/10.6066/jtip.2018.29.2.145
Kurniati. (2015). Buku Ajar Ilmu Penyakit Dalam (Z. Wahab (ed.); Edisi I). Unimus Press.
Luvai, A., Mbagaya, W., Hall, A. S., & Barth, J. H. (2012). Rosuvastatin: A review of the pharmacology and clinical effectiveness in cardiovascular disease. Clinical Medicine Insights: Cardiology, 6, 17–33. https://doi.org/10.4137/CMC.S4324
Marcia. (2003). Rosuvastatin: A New Pharmacotherapy for LDL-Cholesterol Reduction. https://www.clevelandclinicmeded.com/medicalpubs/pharmacy/novdec2003/rosuvastatin.htm
Narita, Y., Kitazoe, Y., Kurihara, Y., Okuhara, Y., Takamatsu, K., Saito, N., & Doi, Y. (1997). Increase or Decrease of HDL-cholesterol Concentrations During Pravastatin Treatment Depending on The Pre-Treatment HDL Cholesterol Levels. European Journal of Clinical Pharmacology, 52(6), 461–463.
Nugraha. (2021). Analisis Penggunaan Golongan Statin pada pasien Hiperkolesterolemia di Rumah Sakit X Abstrak. 3(1).
Nugraha, D. F., Henjani, N., & Magfirah, N. W. (2021). Perbandingan Aktivitas Antihiperlipidemia Infusa Rimpang Temu Mangga dan Daun Ketepeng Cina. Journal of Pharmacy and Science, 6(2), 81–87.
Nuralifah, N., Wahyuni, W., Parawansah, P., & Dwi Shintia, U. (2019). Uji Aktivitas Antihiperlipidemia Ekstrak Etanol Daun Notika (Arcboldiodendron calosericeum Kobuski) Terhadap Kadar Kolesterol Total Tikus (Rattus norvegicus) Jantan Galur Wistar. Journal Syifa Sciences and Clinical Research, 2(1), 1–10. https://doi.org/10.37311/jsscr.v2i1.2704
Nuryani. (2019). Perbandingan Efektivitas Ekstrak Etanol Daun Afrika (Vernonia amygdalina Del.) Dengan Simvastatin Terhadap Kadar Trigliserida Pada Tikus Jantan Galur Wistar Yang Diinduksi Kuning Telur. In Society.
Paramita, S., Aminyoto, M., Ismail, S., & Arung, T. (2018). Anti-hypercholesterolemic effect of extract Zingiber montanum extract.
Posangi, I., Posangi, J., & Wuisan, J. (2013). Efek Ekstrak Daun Sirsak (Annona Muricata L.) Pada Kadar Kolesterol Total Tikus Wistar. Jurnal Biomedik (Jbm), 4(1). https://doi.org/10.35790/jbm.4.1.2012.750
Rabbani, S. A. (2014). Rosuvastatin: A Review Of Pharmacodynamic And Pharmacokinetic Properties. 22(6), 1–117.
Rabie’ah. (2014). Tatalaksana Terkini Dislipidemia. Tinjauan Pustaka, 20(54), 28–33.
Rahardi. (2010). Pengaruh Pemberian Simvastatin terhadap Fungsi Memori Jangka Pendek Tikus Wistar Hiperlipidemi. Fakultas
Kedokteran Universitas Diponegoro, 1–15.
Raharja. (2015). Obat-Obat penting : Khasiat, Penggunaan dan Efek-Efek Sampingnya (7 ed.).
Rahmawati. (2020). Analisis Faktor-Faktor Risiko Kejadian Dislipidemia pada Karyawan Pria Head Office PT.X, Cakung, Jakarta Timur. Nutrire Diaita, 12(01), 1–9. https://doi.org/10.47007/nut.v12i01.3014
Rosyada, S. M. (2013). Perbedaan pengaruh antara ekstrak dan rebusan daun salam (ugenia polyantha) dalam pencegahan peningkatan kadar kolesterol total pada tikus sprague dawley [Skripsi]. Semarang: Prodi Ilmu Gizi Fakultas Kedokteran Universitas Dipenogoro. Prodi Ilmu Gizi Fakultas Kedokteran Universitas Dipenogoro., 1–32.
Sagay, K. S., Siahaan, P., & Mambu, S. (2020). Respon Pertumbuhan Vegetatif Sawi Hijau (Brassica rapa l. Var. Tosakan ) Akibat Pemberian PGPR (Plant Growth Promoting Rhizobacteria) yang Dikombinasikan dengan Pupuk Kompos dan NPK. Jurnal Bios Logos, 10(2), 79. https://doi.org/10.35799/jbl.11.2.2020.29017
Sasaki, J., Otonari, T., Uchida, Y., Ikeda, Y., Biro, S., & Kono, S. (2013). Effects of Pravastatin and Atorvastatin on HDL Cholesterol and Glucose Metabolism in Patients with Dyslipidemia and Glucose Intolerance: The PRAT study. Journal of Atherosclerosis and Thrombosis, 20(4), 368–379. https://doi.org/10.5551/jat.13532
Simatupang. (2017). MONOGRAF Statin (HMG-CoA reductase inhibitor): Bukti Terbaru Pengalaman Penggunaannya.
Tomlinson. (2013). Current perspectives on rosuvastatin. Integrated Blood Pressure Control, 6, 15–25. https://doi.org/10.2147/IBPC.S34814
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Journal Pharmaceutical Care and Sciences
This work is licensed under a Creative Commons Attribution 4.0 International License.
